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Parlodel (Generic)

Parlodel (bromocriptine) inhibits the secretion of the hormone prolactin from the pituitary gland. It also mimics the action of dopamine, a chemical lacking in the brain of someone with Parkinson's disease. It is used to treat a variety of other medical conditions.


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Uses

Treating Parkinson disease, certain conditions caused by too much prolactin in the blood (e.g., excessive or abnormal breast milk production), certain menstrual problems, or abnormally large growth of certain body parts (acromegaly). It may also be used for other conditions as determined by your doctor.
Bromocriptine is a dopamine agonist. It works by blocking the release of prolactin from the pituitary gland and lowering growth hormone levels (in patients with acromegaly). In Parkinson disease, bromocriptine works by stimulating dopamine receptors in certain parts of the brain.

How to take

Take with food or meals to prevent stomach upset. The first dose should be taken lying down as dizziness may occur especially with the first dose.

Side effects

May cause drowsiness. Avoid tasks requiring alertness. Other side effects may include stomach cramps, nausea, vomiting, indigestion, constipation, diarrhea, headache, fatigue, lightheadedness, insomnia, nasal congestion. These should subside as your body adjusts to the medication. If any of these effects persist or worsen, notify your doctor promptly. Notify your doctor if you develop: bloody vomit, confusion, fainting, depression, irregular pulse, shortness of breath, rash, tingling of hands or feet, involuntary movements, nightmares, vision changes. If you notice other effects not listed above, contact your doctor or pharmacist.

Precaution

Some medical conditions may interact with bromocriptine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
·1 if you are pregnant or planning to become pregnant
·2 if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
·3 if you have allergies to medicines, foods, or other substances
·4 if you have angina (chest pain) or coronary artery disease, irregular heartbeat, high blood pressure, kidney disease, liver disease, mental illness, narrowing of blood vessels of the legs or arms, a history of vision problems, or a history of stomach or intestinal bleeding, or if you have had a heart attack

Drug interactions

·1 Sumatriptan because excessive increases in blood pressure may occur
·2 Beta-blockers (e.g., propranolol), sympathomimetics (e.g., albuterol, amphetamine, pseudoephedrine), ergot alkaloids (e.g., ergotamine), HIV protease inhibitors (e.g., ritonavir), ketolides (e.g., telithromycin), macrolides (e.g., erythromycin), medicine for high blood pressure, or NNRT inhibitors (e.g., efavirenz) because the risk of side effects of bromocriptine may be increased
·3 Phenothiazines (e.g., chlorpromazine), haloperidol, metoclopramide, or pimozide because the effectiveness of bromocriptine may be decreased
·4 Methyldopa because side effects, including dizziness upon standing, may be increased by bromocriptine

Missed dose

If you miss a dose, take as soon as remembered within 4 hours, otherwise skip that dose and resume usual dosing schedule. Do not "double-up" the dose to catch up.

Storage

Store below 77 degrees F (below 25 degrees C) away from moisture and sunlight. Do not store in the bathroom. Keep away from children and pets.